ARTERIAL BLOOD GASES AFTER ATROPINE SULPHATE IN HEALTHY VOLUNTEERS

Arterial blood gases after atropine sulphate in healthy volunteers.

Diazepam and meperidine on arterial blood gases in healthy volunteers.

July, 1974 377 TERIAL blood gases and p11 may reflect the respiratory depression produced by tranquilizing and narcoticanalgesic agents used in premedication before surgical anesthesia. The absence of respiratory depression is one of the desirable qualities of an ideal premedicant or sedative drug. Therefore, it is essential to know if, and to what extent, a particular drug depresses respiratio...

Effect of secobarbital and morphine on arterial blood gases in healthy human volunteers.

Secobarbital is still widely used as a hypnotic and morphine as an analgesic perioperatively in surgical patients. Their combination is often used as a preanesthetic medication. Although their ventilatory depressant effect is recognized, the resulting blood gas changes have not been studied as yet adequately in a sufficiently large population of healthy volunteers. Therefore this study was unde...

Effect of hydroxyzine and meperidine on arterial blood gases in healthy human volunteers.

Because hydroxyzine hydrochloride is frequently used to tranquilize patients, who are receiving narcotic analgesics for pain relief, its effect alone and in combination with meperidine on arterial blood gases and ventilation in patients at rest was evaluated in 65 healthy volunteers, who gave informed consent. Hydroxyzine hydrochloride, 1.5 mg/kg IV given over 30 seconds, caused no decrease but...

Comparative effects of hyoscine butylbromide and atropine sulphate on sleep architecture in healthy human volunteers.

The changes in sleep architecture, heart rate and respiratory rate to hyoscine butylbromide (HBB), a peripherally acting anticholinergic was studied. These effects were compared with that of atropine sulphate, a drug known to cross the blood brain barrier. The study followed a single blind cross over design with a one week washout period. Atropine sulphate (0.4 mg) and HBB (10 mg) were given in...